Horizon Pharma plc
Horizon Pharma plc (Form: 8-K, Received: 05/08/2017 07:13:34)

 

 

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549

 

 

FORM 8-K

 

 

CURRENT REPORT

Pursuant to Section 13 or 15(d)

of the Securities Exchange Act of 1934

Date of Report (Date of earliest event reported): May 8, 2017

 

 

Horizon Pharma Public Limited Company

(Exact name of registrant as specified in its charter)

 

 

 

Ireland   001-35238   Not Applicable

(State or other jurisdiction

of incorporation)

 

(Commission

File No.)

 

(IRS Employer

Identification No.)

Connaught House, 1 st Floor, 1 Burlington Road,

Dublin 4, D04 C5Y6, Ireland

(Address of principal executive offices)

Registrant’s telephone number, including area code: 011-353-1-772-2100

 

 

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

 

Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 or Rule 12b-2 of the Securities Exchange Act of 1934.

Emerging growth company  ☐

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act.  ☐

 

 

 


Item 2.02 Results of Operations and Financial Condition.

On May 8, 2017, Horizon Pharma plc issued a press release announcing its financial results for the first quarter ended March 31, 2017. A copy of this press release is attached hereto as Exhibit 99.1.

The information in this Item 2.02 and the exhibit hereto are being furnished and shall not be deemed to be “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), or otherwise subject to the liability of that section, nor shall they be deemed incorporated by reference in any filing under the Securities Act of 1933, as amended, or the Exchange Act, except as expressly set forth by specific reference in such a filing.

 

Item 9.01 Financial Statements and Exhibits.

(d) Exhibits.

 

Exhibit

No.

  

Description

99.1    Press Release dated May 8, 2017


SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

 

Date: May 8, 2017     HORIZON PHARMA PUBLIC LIMITED COMPANY
    By:   /s/ Paul W. Hoelscher
      Paul W. Hoelscher
      Executive Vice President and Chief Financial Officer

Exhibit 99.1

 

LOGO

Horizon Pharma plc Announces First-Quarter 2017 Results and

Revises Full-Year 2017 Net Sales and Adjusted EBITDA Guidance

— First-Quarter 2017 Net Sales of $220.9 Million; Up 8 Percent —

— First-Quarter 2017 Net Loss of $90.6 Million; Adjusted EBITDA of $51.9 Million —

— First-Quarter 2017 Net Sales from Rare Disease Medicines Increased 75 Percent and

Represented 65 Percent of Total Company Net Sales —

— Increased Investment in its Rapidly Growing Orphan Biologic Medicine for Refractory Chronic Gout, KRYSTEXXA ®

— Raising KRYSTEXXA Peak Annual Net Sales Estimate to More than $400 Million from

More than $250 Million –

— Announces Acquisition of River Vision Development Corp. and Teprotumumab, a Biologic

in Late-Stage Development for a Rare Eye Disease –

— Revising Full-Year 2017 Net Sales Guidance Range to $1.000 Billion to $1.035 Billion and

Full-Year 2017 Adjusted EBITDA Guidance Range to $315 Million to $350 Million; Reflects Revisions to the Primary

Care Business Unit Assumptions, Increased Investment in KRYSTEXXA and R&D Investment in Teprotumumab —

— Announces Board of Directors’ Authorization of Share Repurchase Program for Approximately

10 Percent of Shares Outstanding —

DUBLIN, IRELAND May 8, 2017 – Horizon Pharma plc (NASDAQ: HZNP), a biopharmaceutical company focused on improving patients’ lives by identifying, developing, acquiring and commercializing differentiated and accessible medicines that address unmet medical needs, announced its first-quarter 2017 financial results today and revised its full-year 2017 net sales and adjusted EBITDA guidance.

“We generated strong first-quarter performance in our orphan and rheumatology business units, with KRYSTEXXA and RAVICTI achieving record net sales; however, our primary care business unit performed well below our expectations,” said Timothy P. Walbert, chairman, president and chief executive officer, Horizon Pharma plc. “The lower primary care business unit results were related to the implementation of the contracting model with pharmacy benefit managers, which has not performed in accordance with our expectations. While we are proactively addressing this underperformance, with greater visibility into the impact of this transition, we are revising our full-year 2017 net sales and adjusted EBITDA guidance.”

Mr. Walbert added, “We have transformed Horizon Pharma into a company focused on rare disease medicines and we are significantly increasing our investment in one of our key growth drivers, KRYSTEXXA, which we now believe can exceed $400 million in peak annual sales. That investment is supported by our continued expectation of strong cash-flow generation for the year, which also allows us to continue to seek attractive acquisitions, such as River Vision, which we announced today. These actions, in addition to our newly authorized share repurchase program, reflect our confidence in the long-term value of our Company.”

 

1


LOGO

 

Financial Highlights

 

(in millions except for per share amounts and percentages)    Q1 17      Q1 16      %
Change
 

Net sales

   $ 220.9      $ 204.7        8  

Net loss

     (90.6      (45.4      99  

Non-GAAP net income

     35.0        41.3        (15

Adjusted EBITDA

     51.9        72.0        (28

Net loss per share - diluted

     (0.56      (0.28      100  

Non-GAAP earnings per share - diluted

     0.21        0.25        (16

Company Highlights

 

    First-quarter 2017 net sales were $220.9 million, an increase of 8 percent compared to the first quarter of 2016, driven by strong growth from the Company’s orphan and rheumatology business units, offset by lower sales in the primary care business unit.

 

    Net sales of medicines for rare diseases, which include RAVICTI ® , PROCYSBI ® , KRYSTEXXA ® , ACTIMMUNE ® , BUPHENYL ® and QUINSAIR™, increased 75 percent compared to the first quarter of 2016 and represented 65 percent of total net sales. PROCYSBI and QUINSAIR were acquired on October 25, 2016; KRYSTEXXA and MIGERGOT were acquired on January 13, 2016.

 

    On April 28, 2017, the Company received approval for its supplemental New Drug Application (sNDA) with the U.S. Food and Drug Administration (FDA) for RAVICTI to expand the age range for chronic management of urea cycle disorders (UCDs) in patients to two months of age and older from two years of age and older.

 

    On May 8, 2017, the Company announced an agreement to acquire River Vision and its biologic teprotumumab in late stage development for Thyroid Eye Disease (TED). TED is a condition in which the eye muscles and fatty tissue behind the eye become inflamed; causing the eyes to be pushed forward and resulting in debilitating pressure, headaches and decreased vision. The Company estimates there are approximately 10,000 patients in the U.S. with moderate to severe TED, who may be candidates for treatment with teprotumumab, if approved. Under the terms of the acquisition, Horizon is acquiring all outstanding equity of River Vision for a $145 million up-front payment, plus potential future milestone and earn-out payments contingent on the satisfaction of certain regulatory milestones and sales thresholds. The Company anticipates a potential peak annual net sales opportunity for teprotumumab, if approved, in excess of $250 million in the United States. The acquisition is expected to close today.

 

2


LOGO

 

First-Quarter 2017 Business Unit Net Sales Results

 

(in millions except for percentages)    Q1 17      Q1 16      %
Change
 

Orphan

   $ 112.5      $ 66.3        70  

RAVICTI ®

     43.9        37.1        18  

PROCYSBI ® (1)

     34.3        —          NM (2)  

ACTIMMUNE ®

     26.2        25.5        3  

BUPHENYL ®

     6.3        3.7        69  

QUINSAIR TM(1)

     1.8        —          NM  

Rheumatology

     42.8        27.4        56  

KRYSTEXXA ® (3)

     31.6        16.2        96  

RAYOS ®

     10.3        10.5        (2

LODOTRA ®

     0.9        0.7        24  

Primary Care

     65.6        111.0        (41

PENNSAID ® 2%

     41.6        55.0        (24

DUEXIS ®

     17.7        29.6        (40

VIMOVO ®

     4.9        25.5        (81

MIGERGOT ® (3)

     1.4        0.9        57  
  

 

 

    

 

 

    

 

 

 

Total net sales

   $ 220.9      $ 204.7        8  
  

 

 

    

 

 

    

 

(1) PROCYSBI and QUINSAIR were acquired on October 25, 2016.
(2) Q1 16 pre-acquisition net sales of PROCYSBI were $27.5 million.
(3) KRYSTEXXA and MIGERGOT were acquired on January 13, 2016.

 

    Orphan Business Unit:  First-quarter orphan business unit net sales increased 70 percent compared to the first quarter of 2016.

RAVICTI net sales in the first quarter of 2017 were $43.9 million, an increase of 18 percent compared to the first quarter of 2016. The Company expects RAVICTI to be launched in Europe later in 2017 in partnership with Swedish Orphan Biovitrum AB (SOBI).

PROCYSBI net sales in the first quarter of 2017 were $34.3 million, up 25 percent compared to Raptor’s pre-acquisition net sales of $27.5 million in the first quarter of 2016, driven by continued strong patient demand from both patients converting from older-generation therapy as well as treatment-naïve patients.

ACTIMMUNE net sales in the first quarter of 2017 were $26.2 million, an increase of 3 percent versus the first quarter of 2016. The Company has evolved its strategy to establish the role of ACTIMMUNE in a broader range of chronic granulomatous disease patients and ACTIMMUNE remains on track to return to growth for the full-year 2017.

 

3


LOGO

 

The Company continues to make progress in the Phase 1 dose escalation trial evaluating ACTIMMUNE as part of a combination therapy in solid tumors for certain cancers. In February, preliminary data presented at the American Society of Clinical Oncology Clinical Immuno-Oncology Symposium conference showed that combination therapy of ACTIMMUNE with nivolumab, a PD-1 inhibitor, was safe and well-tolerated in the first two cohorts. The data also showed statistically significant activation of certain monocytes, or white blood cells in peripheral blood, which demonstrates that ACTIMMUNE is having the desired effect of stimulating immune cells. These are early results, and the third cohort of patients is still under study. In the first quarter of 2017, a fourth cohort was added to the study to more fully assess dose response. In addition, a number of academic and clinical institutions have expressed interest in studying ACTIMMUNE as combination therapy in certain cancers, including the National Cancer Institute, which plans to initiate a study later this year to treat patients with Cutaneous T-Cell Lymphoma (CTCL) with ACTIMMUNE and pembrolizumab, a PD-1 inhibitor.

The acquisition of River Vision provides the Company with teprotumumab, a fully human monoclonal antibody that targets Insulin-like Growth Factor-1 receptor (IGF-1R). Teprotumumab is in late-stage development for TED, and has received Orphan Drug, Fast Track and Breakthrough Therapy designations from the FDA. On May 4, 2017, The New England Journal of Medicine published teprotumumab Phase 2 study results that demonstrate significant clinical efficacy in TED. Teprotumumab was also safe and well tolerated. The Company expects to begin a Phase 3 pivotal program of teprotumumab in TED in the second half of 2017.

 

    Rheumatology Business Unit:   KRYSTEXXA net sales in the first quarter of 2017 were $31.6 million, an increase of 96 percent compared to the first quarter of 2016. Since acquiring the medicine in January of 2016, the Company’s improved commercial strategy and additional investment in commercial, education and outreach efforts has rapidly accelerated KRYSTEXXA net sales.

Based on the continued increase in uptake of KRYSTEXXA and the clear unmet need that exists for thousands of refractory chronic gout sufferers, the Company will significantly increase its infrastructure and investment in the medicine. Beginning in the second quarter and continuing through the second half of 2017, the Company will expand its commercial organization to nearly 200 employees from more than 100. With the additional resources, the Company expects to expand its reach to physicians and increase awareness of refractory chronic gout among physicians and patients. As a result, the Company now expects KRYSTEXXA annual peak net sales of more than $400 million versus the previous estimate of more than $250 million.

 

    Primary Care Business Unit: Total net sales for the primary care business unit were $65.6 million in the first quarter of 2017. Net sales of PENNSAID 2%, DUEXIS and VIMOVO in the first quarter of 2017 were $41.6 million, $17.7 million and $4.9 million, respectively.

 

4


LOGO

 

During the second half of 2016, the Company entered into rebate agreements with pharmacy benefit managers (PBMs) in an effort to secure broader inclusion of its primary care medicines on healthcare plan formularies. This transition to PBM rebate agreements, most of which became effective January 1, 2017, was a change to the commercial model of the Company’s primary care business unit, and following this transition, first-quarter 2017 primary care business unit net sales were lower than the Company’s expectations.

Total prescription volumes for DUEXIS, VIMOVO and PENNSAID 2% were approximately in line with the Company’s expectations in the first quarter of 2017. However, the average net realized price (ANRP) was significantly below expectations due to higher patient assistance costs and higher PBM rebate levels than anticipated. This was a function of lower-than-anticipated adoption rates of the Company’s primary care medicines onto certain healthcare plan formularies (custom clients), resulting in higher patient assistance costs to the Company, as well as fact that PBM plans that covered the Company’s primary care medicines are primarily plans that require a higher rebate (PBM-chosen formulary clients), resulting in higher rebate costs. To a lesser extent, the lower ANRP in the quarter was also due to a higher rate of managed care control in the Company’s non-contracted business, reflecting an industry-wide trend.

PBM clients broadly fall into two categories, clients that follow a PBM-chosen formulary and clients where the PBM works on their behalf to provide customized formularies (custom clients). Rebate amounts paid to the PBMs for custom clients are typically lower than rebate amounts paid to the PBM for PBM-chosen formulary clients.

When the Company established its financial guidance for full-year 2017, the Company estimated the adoption trajectory and mix of PBM clients that the change to its commercial model would generate. This took into account input from the PBMs. The Company did not have full visibility into the actual PBM client mix and the magnitude of the difference compared to its assumptions until it received detailed PBM invoices in late April and early May.

While the Company continues to work to drive adoption of its medicines with custom clients, it now expects a much lower level of adoption of custom client plans in 2017. Compared to its previous financial guidance, the Company has incorporated a higher level of rebates, a higher level of patient assistance costs and a lower level of total prescription volume into its full-year 2017 primary care business unit net sales forecast. It is also reducing certain primary care business unit operating costs as well as other company costs to align its cost structure with revised net sales expectations. As a result, the Company has lowered its full-year 2017 net sales and adjusted EBITDA guidance.

 

5


LOGO

 

First-Quarter 2017 Financial Results

Note: For additional detail and reconciliation of non-GAAP financial measures to the most directly comparable GAAP financial measures, please refer to the tables at the end of this release.

 

    Gross Profit: Under U.S. GAAP in the first quarter of 2017, the gross profit ratio was 37.0 percent compared to 62.3 percent in the first quarter of 2016. The non-GAAP gross profit ratio in the first quarter of 2017 was 88.5 percent compared to 90.6 percent in the first quarter of 2016.

 

    Operating Expenses: On a GAAP basis in the first quarter of 2017, total operating expenses were 84.7 percent of net sales. Non-GAAP total operating expenses in the first quarter of 2017 were 64.8 percent of net sales. Research & development (R&D) expenses were 5.9 percent of net sales; and selling, general and administrative (SG&A) expenses were 78.8 percent of net sales. Non-GAAP R&D expenses were 4.9 percent of net sales, and non-GAAP SG&A expenses were 59.9 percent of net sales. In the first quarter, the Company began to combine sales and marketing and general and administrative into a single expense line item – selling, general and administrative, or SG&A. The Company will report expenses on this basis going forward. (Please see tables for historical SG&A at the end of this release.)

 

    Income Tax Rate: The income tax rate in the first quarter of 2017 on a GAAP basis was 34.4 percent and on a non-GAAP basis was negative 37.0 percent. The favorable first-quarter non-GAAP tax rate related to the fact that the GAAP pretax loss of $138.1 million generated a $47.5 million GAAP tax benefit, which was offset by $38.1 million of tax expense on the non-GAAP adjustments, calculated at statutory rates.

 

    Net (Loss) Income: On a GAAP basis in the first quarter of 2017, net loss was $90.6 million. Non-GAAP net income was $35.0 million.

 

    EBITDA: In the first quarter of 2017, EBITDA was $18.7 million. Adjusted EBITDA in the first quarter of 2017 was $51.9 million.

 

    Earnings (Loss) per Share: On a GAAP basis in the first quarter of 2017, diluted loss per share was $0.56; in the first quarter of 2016, diluted loss per share was $0.28. Non-GAAP diluted earnings per share in the first quarter of 2017 and 2016 were $0.21 and $0.25, respectively. Weighted average shares outstanding used for calculating GAAP diluted loss per share and non-GAAP diluted earnings per share in the first quarter of 2017 were 162.0 million and 164.9 million, respectively.

Cash Flow Statement and Balance Sheet Highlights

 

    On a GAAP basis in the first quarter of 2017, operating cash flow was $20.7 million. Non-GAAP operating cash flow was $65.2 million in the first quarter of 2017.

 

    The Company had cash and cash equivalents of $603.4 million as of March 31, 2017.

 

6


LOGO

 

    In the first quarter, the Company refinanced its senior secured term loans. The Company realized a lower interest rate and extended the maturity date from 2021 to 2024. Total principal amount of debt outstanding as of March 31, 2017, was $2.025 billion, which was composed of $850 million in senior secured term loans due 2024; $475 million senior notes due 2023; $300 million senior notes due 2024; and $400 million exchangeable senior notes due 2022. Net debt as of March 31, 2017 was $1.422 billion.

Full-Year 2017 Guidance

For the full-year 2017, the Company expects continued strong net sales growth for both its orphan and rheumatology businesses, driven primarily by strong patient growth in KRYSTEXXA, RAVICTI and PROCYSBI. In its primary care business unit, the Company is assuming net sales of more than $300 million.

As a result of these expectations, the Company revised its full-year 2017 net sales guidance range to $1.000 billion to $1.035 billion from $1.240 billion to $1.290 billion. The Company revised its full-year 2017 adjusted EBITDA guidance to $315 million to $350 million from $525 million to $575 million, which assumes the lower net sales range and accounts for cost reductions, primarily in its primary care business, and a reinvestment of a portion of these reductions in KRYSTEXXA to maximize its long-term potential. It also reflects an approximate $20 million increase in operating expenses, primarily in R&D, for full-year 2017 related to teprotumumab. The Company is raising its estimate of peak annual net sales for KRYSTEXXA to $400 million from $250 million.

Conference Call

At 7:30 a.m. EST / 12:30 p.m. IST today, the Company will host a live conference call and webcast to review its financial and operating results and provide a general business update.

U.S. Dial-In Number: +1 888.338.8373

International Dial-In Number: +1 973.872.3000

Passcode: 4624726

The live webcast and a replay may be accessed by visiting Horizon’s website at http://ir.horizon-pharma.com . Please connect to the Company’s website at least 15 minutes prior to the live webcast to ensure adequate time for any software download that may be needed to access the webcast.

A replay of the conference call will be available approximately two hours after the call and accessible through one of the following telephone numbers, using the passcode below:

Replay U.S. Dial-In Number: +1 855.859.2056

Replay International Dial-In Number: +1 404.537.3406

Passcode: 4624726

 

7


LOGO

 

About Horizon Pharma plc

Horizon Pharma plc is a biopharmaceutical company focused on improving patients’ lives by identifying, developing, acquiring and commercializing differentiated and accessible medicines that address unmet medical needs. The Company markets 11 medicines through its orphan, rheumatology and primary care business units. For more information, please visit www.horizonpharma.com . Follow @HZNPplc on Twitter or view careers on our LinkedIn page.

Note Regarding Use of Non-GAAP Financial Measures

EBITDA, or earnings before interest, taxes, depreciation and amortization, and adjusted EBITDA are used and provided by Horizon Pharma as non-GAAP financial measures. Horizon Pharma provides certain other financial measures such as non-GAAP net income, non-GAAP diluted earnings per share, non-GAAP gross profit and gross profit ratio, non-GAAP operating expenses, non-GAAP tax rate and non-GAAP operating cash flow, each of which include adjustments to GAAP figures. These non-GAAP measures are intended to provide additional information on Horizon Pharma’s performance, operations, expenses, profitability and cash flows. Adjustments to Horizon Pharma’s GAAP figures as well as EBITDA exclude acquisition-related expenses, charges related to the discontinuation of ACTIMMUNE development for Friedreich’s ataxia, an upfront fee for a license of a patent, a litigation settlement, loss on debt extinguishment and loss on sale of long-term investments, costs of debt refinancing, drug manufacturing harmonization costs, as well as non-cash items such as share-based compensation, depreciation and amortization, royalty accretion, non-cash interest expense, intangible and other non-current asset impairment charges, and other non-cash adjustments. Certain other special items or substantive events may also be included in the non-GAAP adjustments periodically when their magnitude is significant within the periods incurred. Horizon Pharma maintains an established non-GAAP cost policy that guides the determination of what costs will be excluded in non-GAAP measures. Horizon Pharma believes that these non-GAAP financial measures, when considered together with the GAAP figures, can enhance an overall understanding of Horizon Pharma’s financial and operating performance. The non-GAAP financial measures are included with the intent of providing investors with a more complete understanding of the Company’s historical and expected 2017 financial results and trends and to facilitate comparisons between periods and with respect to projected information. In addition, these non-GAAP financial measures are among the indicators Horizon Pharma’s management uses for planning and forecasting purposes and measuring the Company’s performance. For example, adjusted EBITDA is used by Horizon Pharma as one measure of management performance under certain incentive compensation arrangements. These non-GAAP financial measures should be considered in addition to, and not as a substitute for, or superior to, financial measures calculated in accordance with GAAP. The non-GAAP financial measures used by the Company may be calculated differently from, and therefore may not be comparable to, non-GAAP financial measures used by other companies. Horizon Pharma has not provided a reconciliation of its full-year 2017 adjusted EBITDA outlook to an expected net income (loss) outlook because certain items such as acquisition-related expenses and share-based compensation that are a component of net income (loss) cannot be reasonably projected due to the significant impact of changes in Horizon Pharma’s stock price, the variability associated with the size or timing of acquisitions and other factors. These components of net income (loss) could significantly impact Horizon Pharma’s actual net income (loss).

Forward-Looking Statements

This press release contains forward-looking statements, including, but not limited to, statements related to Horizon Pharma’s full-year 2017 net sales and adjusted EBITDA guidance, expected peak annual sales of KRYSEXXA, growth of 2017 ACTIMMUNE net sales and 2017 nets sales of Horizon Pharma’s primary care business unit medicines, expected financial performance in future periods, expected timing of clinical, regulatory and commercial events, including the planned Phase 3 pivotal clinical trial of teprotumumab and anticipated additional clinical trials of ACTIMMUNE in cancer indications, the timing and potential benefits of Horizon Pharma’s acquisition of River Vision, planned reductions in the Company’s primary care operating expenses and increases in R&D investment and

 

8


LOGO

 

KRYSTEXXA commercialization spending, the expected future impact of Horizon Pharma’s primary care business unit’s PBM contracting commercial model, the expected launch of RAVICTI in Europe, potential market opportunity for Horizon Pharma’s medicines in approved and potential additional indications, potential growth of Horizon Pharma’s medicines and business and other statements that are not historical facts. These forward-looking statements are based on Horizon Pharma’s current expectations and inherently involve significant risks and uncertainties. Actual results and the timing of events could differ materially from those anticipated in such forward-looking statements as a result of these risks and uncertainties, which include, without limitation, risks that Horizon Pharma’s actual future financial and operating results may differ from its expectations or goals; Horizon Pharma’s ability to grow net sales from existing products; the availability of coverage and adequate reimbursement and pricing from government and third-party payers and risks relating to Horizon Pharma’s ability to successfully implement its business strategies; whether Horizon Pharma is able to realize expected benefits from arrangements with PBMs; risks related to acquisition integration and achieving projected benefits; risks associated with clinical development and regulatory approvals; risks in the ability to recruit, train and retain qualified personnel; competition, including potential generic competition; the ability to protect intellectual property and defend patents; regulatory obligations and oversight, including any changes in the legal and regulatory environment in which Horizon Pharma operates and those risks detailed from time-to-time under the caption “Risk Factors” and elsewhere in Horizon Pharma’s filings and reports with the SEC. Horizon Pharma undertakes no duty or obligation to update any forward-looking statements contained in this presentation as a result of new information.

Contacts:

 

Investors:

  

U.S. Media:

Tina Ventura

  

Geoff Curtis

Senior Vice President,

  

Senior Vice President,

Investor Relations

  

Corporate Communications

investor-relations@horizonpharma.com

  

media@horizonpharma.com

Ruth Venning

  

Ireland Media:

 

Executive Director,

  

Ray Gordon

Investor Relations

  

Gordon MRM

investor-relations@horizonpharma.com

  

ray@gordonmrm.ie

 

9


LOGO

 

Horizon Pharma plc

Condensed Consolidated Statements of Operations (Unaudited)

(in thousands, except share and per share data)

 

     Three Months Ended March 31,  
     2017     2016  

Net sales

   $ 220,859     $ 204,690  

Cost of goods sold

     139,116       77,233  
  

 

 

   

 

 

 

Gross profit

     81,743       127,457  
  

 

 

   

 

 

 

OPERATING EXPENSES:

    

Research and development

     13,061       12,722  

Selling, general and administrative

     174,065       141,939  
  

 

 

   

 

 

 

Total operating expenses

     187,126       154,661  
  

 

 

   

 

 

 

Operating loss

     (105,383     (27,204
  

 

 

   

 

 

 

OTHER EXPENSE, NET:

    

Interest expense, net

     (31,983     (19,458

Foreign exchange loss

     (259     (173

Loss on debt extinguishment

     (533     —    

Other income (expense), net

     35       (14
  

 

 

   

 

 

 

Total other expense, net

     (32,740     (19,645
  

 

 

   

 

 

 

Loss before benefit for income taxes

     (138,123     (46,849

BENEFIT FOR INCOME TAXES

     (47,553     (1,443
  

 

 

   

 

 

 

NET LOSS

   $ (90,570   $ (45,406
  

 

 

   

 

 

 

Net loss per ordinary share - basic and diluted

   $ (0.56   $ (0.28
  

 

 

   

 

 

 

Weighted average ordinary shares outstanding - basic and diluted

     161,972,052       159,904,416  
  

 

 

   

 

 

 

 

10


LOGO

 

Horizon Pharma plc

Condensed Consolidated Balance Sheets (Unaudited)

(in thousands, except share data)

 

     As of  
     March 31,
2017
    December 31,
2016
 

ASSETS

  

CURRENT ASSETS:

    

Cash and cash equivalents

   $ 603,358     $ 509,055  

Restricted cash

     6,989       7,095  

Accounts receivable, net

     396,785       305,725  

Inventories, net

     137,839       174,788  

Prepaid expenses and other current assets

     52,091       49,619  
  

 

 

   

 

 

 

Total current assets

     1,197,062       1,046,282  
  

 

 

   

 

 

 

Property and equipment, net

     23,557       23,484  

Developed technology, net

     2,697,710       2,767,184  

Other intangible assets, net

     6,048       6,251  

Goodwill

     445,579       445,579  

Deferred tax assets, net

     1,957       911  

Other assets

     2,843       2,368  
  

 

 

   

 

 

 

TOTAL ASSETS

   $ 4,374,756     $ 4,292,059  
  

 

 

   

 

 

 

LIABILITIES AND SHAREHOLDERS’ EQUITY

    

CURRENT LIABILITIES:

    

Long-term debt—current portion

   $ 8,500     $ 7,750  

Accounts payable

     87,739       52,479  

Accrued expenses

     144,846       182,765  

Accrued trade discounts and rebates

     413,643       297,556  

Accrued royalties—current portion

     60,307       61,981  

Deferred revenues—current portion

     2,935       3,321  
  

 

 

   

 

 

 

Total current liabilities

     717,970       605,852  
  

 

 

   

 

 

 

LONG-TERM LIABILITIES:

    

Exchangeable notes, net

     301,942       298,002  

Long-term debt, net, net of current

     1,578,820       1,501,741  

Accrued royalties, net of current

     273,191       272,293  

Deferred revenues, net of current

     7,639       7,763  

Deferred tax liabilities, net

     242,708       296,568  

Other long-term liabilities

     46,808       46,061  
  

 

 

   

 

 

 

Total long-term liabilities

     2,451,108       2,422,428  
  

 

 

   

 

 

 

COMMITMENTS AND CONTINGENCIES

    

SHAREHOLDERS’ EQUITY:

    

Ordinary shares, $0.0001 nominal value; 300,000,000 shares authorized; 163,008,960 and 162,004,956 issued at March 31, 2017 and December 31, 2016 respectively, and 162,624,594 and 161,620,590 outstanding at March 31, 2017 and December 31, 2016, respectively

     16       16  

Treasury stock, 384,366 ordinary shares at March 31, 2017 and December 31, 2016

     (4,585     (4,585

Additional paid-in capital

     2,144,385       2,119,455  

Accumulated other comprehensive loss

     (2,758     (3,086

Accumulated deficit

     (931,380     (848,021
  

 

 

   

 

 

 

Total shareholders’ equity

     1,205,678       1,263,779  
  

 

 

   

 

 

 

TOTAL LIABILITIES AND SHAREHOLDERS’ EQUITY

   $ 4,374,756     $ 4,292,059  
  

 

 

   

 

 

 

 

11


LOGO

 

Horizon Pharma plc

Condensed Consolidated Statements of Cash Flows (Unaudited)

(in thousands)

 

     Three Months Ended March 31,  
     2017     2016  

CASH FLOWS FROM OPERATING ACTIVITIES:

    

Net loss

   $ (90,570   $ (45,406

Adjustments to reconcile net loss to net cash provided by operating activities

    

Depreciation and amortization expense

     71,483       50,642  

Equity-settled share-based compensation

     28,837       27,745  

Royalty accretion

     12,959       9,359  

Royalty liability remeasurement

     (2,944     —    

Loss on debt extinguishment

     388       —    

Payments related to term loan refinancing

     (3,940     —    

Amortization of debt discount and deferred financing costs

     5,423       4,425  

Deferred income taxes

     (47,695     (2,657

Foreign exchange and other adjustments

     787       173  

Changes in operating assets and liabilities:

    

Accounts receivable

     (91,058     (69,838

Inventories

     37,050       7,317  

Prepaid expenses and other current assets

     (2,445     (242

Accounts payable

     36,078       52,856  

Accrued trade discounts and rebates

     116,079       40,601  

Accrued expenses and accrued royalties

     (49,359     (23,521

Deferred revenues

     (618     (498

Other non-current assets and liabilities

     266       3,225  
  

 

 

   

 

 

 

Net cash provided by operating activities

     20,721       54,181  
  

 

 

   

 

 

 

CASH FLOWS FROM INVESTING ACTIVITIES:

    

Payments for acquisitions, net of cash acquired

     —         (514,814

Change in restricted cash

     104       (918

Purchases of property and equipment

     (1,421     (7,525
  

 

 

   

 

 

 

Net cash used in investing activities

     (1,317     (523,257
  

 

 

   

 

 

 

CASH FLOWS FROM FINANCING ACTIVITIES:

    

Net proceeds from term loans

     847,768       —    

Repayment of term loans

     (768,665     (1,000

Refunds related to the ESPP plan

     (173     —    

Proceeds from the issuance of ordinary shares in connection with stock option exercises

     544       919  

Payment of employee withholding taxes related to share-based awards

     (4,277     (4,185
  

 

 

   

 

 

 

Net cash provided by (used in) financing activities

     75,197       (4,266
  

 

 

   

 

 

 

Effect of foreign exchange rate changes on cash and cash equivalents

     (298     (421
  

 

 

   

 

 

 

NET INCREASE (DECREASE) IN CASH AND CASH EQUIVALENTS

     94,303       (473,763

CASH AND CASH EQUIVALENTS, beginning of the period

     509,055       859,616  
  

 

 

   

 

 

 

CASH AND CASH EQUIVALENTS, end of the period

   $ 603,358     $ 385,853  
  

 

 

   

 

 

 

 

12


LOGO

 

Horizon Pharma plc

Presentation of Selling, General and Administrative Expenses (Unaudited)

(in thousands)

 

     Q1 16      Q2 16      Q3 16      Q4 16      FY 16  

Previous presentation: Sales and marketing

   $ 75,544      $ 79,589      $ 72,564      $ 92,669      $ 320,366  

General and administrative

     66,395        53,986        59,485        108,076        287,942  
  

 

 

    

 

 

    

 

 

    

 

 

    

 

 

 

Current presentation: Selling, general and administrative

   $ 141,939      $ 133,575      $ 132,049      $ 200,745      $ 608,308  
  

 

 

    

 

 

    

 

 

    

 

 

    

 

 

 
     Q1 15      Q2 15      Q3 15      Q4 15      FY 15  

Previous presentation: Sales and marketing

   $ 47,063      $ 58,056      $ 51,973      $ 63,352      $ 220,444  

General and administrative

     26,280        77,190        54,516        61,875        219,861  
  

 

 

    

 

 

    

 

 

    

 

 

    

 

 

 

Current presentation: Selling, general and administrative

   $ 73,343      $ 135,246      $ 106,489      $ 125,227      $ 440,305  
  

 

 

    

 

 

    

 

 

    

 

 

    

 

 

 

 

13


LOGO

 

Horizon Pharma plc

GAAP to Non-GAAP Reconciliations

Net Income and Earnings Per Share (Unaudited)

(in thousands, except share and per share data)

 

     Three Months Ended March 31,  
     2017     2016  

GAAP net loss

   $ (90,570   $ (45,406

Non-GAAP adjustments:

    

Remeasurement of royalties for medicines acquired through business combinations

     (2,944     —    

Acquisition-related costs

     10,039       11,016  

Upfront fee for license of global patent

     —         2,000  

Loss on debt extinguishment

     533       —    

Fees related to term loan refinancing

     4,143       —    

Amortization, accretion and step-up:

    

Intangible amortization expense

     69,677       49,650  

Amortization of debt discount and deferred financing costs

     5,423       4,425  

Accretion of royalty liabilities

     12,959       9,359  

Inventory step-up expense

     40,595       7,446  

Share-based compensation

     28,469       27,612  

Depreciation expense

     1,806       992  

Drug substance harmonization costs

     4,299       —    

Royalties for medicines acquired through business combinations

     (11,317     (8,500
  

 

 

   

 

 

 

Total of pre-tax non-GAAP adjustments

     163,682       104,000  

Income tax effect of pre-tax non-GAAP adjustments

     (38,103     (17,274
  

 

 

   

 

 

 

Total of non-GAAP adjustments

     125,579       86,726  
  

 

 

   

 

 

 

Non-GAAP Net Income

   $ 35,009     $ 41,320  
  

 

 

   

 

 

 

Non-GAAP Earnings Per Share:

    

Weighted average shares - Basic

     161,972,052       159,904,416  
  

 

 

   

 

 

 

Non-GAAP Earnings Per Share - Basic:

    

GAAP loss per share - Basic

     (0.56     (0.28

Non-GAAP adjustments

     0.78       0.54  
  

 

 

   

 

 

 

Non-GAAP earnings per share - Basic

     0.22       0.26  
  

 

 

   

 

 

 

Weighted average shares - Diluted

    

Weighted average shares - Basic

     161,972,052       159,904,416  

Ordinary share equivalents

     2,895,016       3,756,579  
  

 

 

   

 

 

 

Weighted average shares - Diluted

     164,867,068       163,660,995  
  

 

 

   

 

 

 

Non-GAAP Earnings Per Share - Diluted

    

GAAP loss per share - Diluted

     (0.56     (0.28

Non-GAAP adjustments

     0.78       0.54  

Diluted earnings per share effect of ordinary share equivalents

     (0.01     (0.01
  

 

 

   

 

 

 

Non-GAAP earnings per share - Diluted

     0.21       0.25  
  

 

 

   

 

 

 

 

14


LOGO

 

Horizon Pharma plc

GAAP to Non-GAAP Reconciliations

EBITDA, Gross Profit and Operating Cash Flow (Unaudited)

(in thousands, except percentages)

 

     Three Months Ended March 31,  
     2017     2016  

EBITDA and Adjusted EBITDA:

    

GAAP net loss

   $ (90,570   $ (45,406

Depreciation

     1,806       992  

Amortization, accretion and step-up:

    

Intangible amortization expense

     69,677       49,650  

Accretion of royalty liabilities

     12,959       9,359  

Amortization of deferred revenue

     (204     (206

Inventory step-up expense

     40,595       7,446  

Interest expense, net (including amortization of debt discount and deferred financing costs)

     31,983       19,458  

Benefit for income taxes

     (47,553     (1,443
  

 

 

   

 

 

 

EBITDA

   $ 18,693     $ 39,850  
  

 

 

   

 

 

 

Non-GAAP adjustments:

    

Remeasurement of royalties for medicines acquired through business combinations

     (2,944     —    

Acquisition-related costs

     10,039       11,016  

Upfront fee for license of global patent

     —         2,000  

Loss on debt extinguishment

     533       —    

Fees related to term loan refinancing

     4,143       —    

Share-based compensation

     28,469       27,612  

Drug substance harmonization costs

     4,299       —    

Royalties for medicines acquired through business combinations

     (11,317     (8,500
  

 

 

   

 

 

 

Total of Non-GAAP adjustments

     33,222       32,128  
  

 

 

   

 

 

 

Adjusted EBITDA

   $ 51,915     $ 71,978  
  

 

 

   

 

 

 

Non-GAAP Gross Profit:

    

GAAP gross profit

   $ 81,743     $ 127,457  

Non-GAAP gross profit adjustments:

    

Acquisition-related costs

     80       115  

Share-based compensation

     428       —    

Remeasurement of royalties for medicines acquired through business combinations

     (2,944     —    

Intangible amortization expense (COGS only)

     69,474       49,447  

Accretion of royalty liabilities

     12,959       9,359  

Inventory step-up expense

     40,595       7,446  

Depreciation (COGS only)

     183       120  

Drug substance harmonization costs

     4,299       —    

Royalties for medicines acquired through business combinations

     (11,317     (8,500
  

 

 

   

 

 

 

Total of Non-GAAP adjustments

     113,757       57,987  
  

 

 

   

 

 

 

Non-GAAP gross profit

   $ 195,500     $ 185,444  
  

 

 

   

 

 

 

GAAP gross profit %

     37.0     62.3

Non-GAAP gross profit %

     88.5     90.6

Non-GAAP operating cash flow:

    

GAAP cash provided by operating activities

   $ 20,721     $ 54,181  

Cash payments for acquisition-related costs

     20,392       11,694  

Cash payment for litigation settlement

     16,250       —    

Cash payments for upfront fee for license of global patent

     —         2,000  

Cash payments for clinical trial wind-down costs

     482       —    

Cash payment for debt extinguishment

     145       —    

Cash payments relating to term loan refinancing

     7,252       —    
  

 

 

   

 

 

 

Non-GAAP operating cash flow

   $ 65,242     $ 67,875  
  

 

 

   

 

 

 

 

15


LOGO

 

Horizon Pharma plc

GAAP to Non-GAAP Tax Rate Reconciliation (Unaudited)

(in millions, except percentages)

 

     Q1 17  
     Pre-tax Net
(Loss) Income
    Income Tax
(Benefit) Expense
    Tax Rate     Net (Loss)
Income
    Diluted (Loss)
Earnings Per Share
 

As reported - GAAP

   $ (138.1   $ (47.6     34.4   $ (90.6   $ (0.56

Non-GAAP adjustments

     163.7       38.1         125.7    
  

 

 

   

 

 

   

 

 

   

 

 

   

 

 

 

Non-GAAP

   $ 25.6     $ (9.4     -37.0   $ 35.0     $ 0.21  
  

 

 

   

 

 

   

 

 

   

 

 

   

 

 

 
     Q1 16  
     Pre-tax Net
(Loss) Income
    Income Tax
(Benefit) Expense
    Tax Rate     Net (Loss)
Income
    Diluted (Loss)
Earnings Per Share
 

As reported - GAAP

   $ (46.8   $ (1.4     3.1   $ (45.4   $ (0.28

Non-GAAP adjustments

     104.0       17.3         86.7    
  

 

 

   

 

 

   

 

 

   

 

 

   

 

 

 

Non-GAAP

   $ 57.2     $ 15.9       27.7   $ 41.3     $ 0.25  
  

 

 

   

 

 

   

 

 

   

 

 

   

 

 

 

 

16


LOGO

 

Horizon Pharma plc

Certain Income Statement Line Items - Non-GAAP Adjusted

For the Three Months Ended March 31, 2017 and March 31, 2016

(in thousands) (Unaudited)

 

    

Horizon Pharma plc

Certain Income Statement Line Items - Non-GAAP Adjusted

For the Three Months Ended March 31, 2017

(Unaudited)

 
     COGS     Research &
Development
    Selling, General
& Administrative
    Interest
Expense
    Loss on Debt
Extinguishment
    Income Tax
Benefit
(Expense)
 

GAAP as reported

   $ (139,116   $ (13,061   $ (174,065   $ (31,983   $ (533   $ 47,553  

Non-GAAP Adjustments (in thousands):

            

Acquisition-related costs (1)

     80       177       9,782       —         —         —    

Loss on debt extinguistment (2)

     —         —         —         —         533       —    

Fees related to term loan refinancing (3)

     —         —         4,143       —         —         —    

Amortization, accretion and step-up:

            

Intangible amortization expense (4)

     69,474       —         203       —         —         —    

Amortization of debt discount and deferred financing costs (5)

     —         —         —         5,423       —         —    

Accretion of royalty liability (6)

     12,959       —         —         —         —         —    

Inventory step-up expense (7)

     40,595       —         —         —         —         —    

Remeasurement of royalties for products acquired through business combinations (8)

     (2,944     —         —         —         —         —    

Share-based compensation (9)

     428       2,049       25,992       —         —         —    

Depreciation expense (10)

     183       —         1,623       —         —         —    

Drug substance harmonization costs (11)

     4,299       —            

Royalties for medicines acquired through business combinations (12)

     (11,317     —         —         —         —         —    

Income tax effect on pre-tax non-GAAP adjustments (13)

     —         —         —         —         —         (38,103
  

 

 

   

 

 

   

 

 

   

 

 

   

 

 

   

 

 

 

Total of non-GAAP adjustments

     113,757       2,226       41,743       5,423       533       (38,103
  

 

 

   

 

 

   

 

 

   

 

 

   

 

 

   

 

 

 

Non-GAAP

   $ (25,359   $ (10,835   $ (132,322   $ (26,560   $ —       $ 9,450  
  

 

 

   

 

 

   

 

 

   

 

 

   

 

 

   

 

 

 

 

    

Horizon Pharma plc

Certain Income Statement Line Items - Non-GAAP Adjusted

For the Three Months Ended March 31, 2016

(Unaudited)

 
     COGS     Research &
Development
    Selling, General
& Administrative
    Interest
Expense
    Income Tax
Benefit
(Expense)
 

GAAP as reported

   $ (77,233   $ (12,722   $ (141,939   $ (19,458   $ 1,443  

Non-GAAP Adjustments (in thousands):

          

Acquisition-related costs (1)

     115       32       10,869       —         —    

Upfront fee for license of global patent (14)

     —         2,000       —         —         —    

Amortization, accretion and step-up:

          

Intangible amortization expense (4)

     49,447       —         203       —         —    

Amortization of debt discount and deferred financing costs (5)

     —         —         —         4,425       —    

Accretion of royalty liability (6)

     9,359       —         —         —         —    

Inventory step-up expense (7)

     7,446       —         —         —         —    

Share-based compensation (9)

     —         2,125       25,487       —         —    

Depreciation expense (10)

     120       —         872       —         —    

Royalties for medicines acquired through business combinations (12)

     (8,500     —         —         —         —    

Income tax effect on pre-tax non-GAAP adjustments (13)

     —         —         —         —         (17,274
  

 

 

   

 

 

   

 

 

   

 

 

   

 

 

 

Total of non-GAAP adjustments

     57,987       4,157       37,431       4,425       (17,274
  

 

 

   

 

 

   

 

 

   

 

 

   

 

 

 

Non-GAAP

   $ (19,246   $ (8,565   $ (104,508   $ (15,033   $ (15,831
  

 

 

   

 

 

   

 

 

   

 

 

   

 

 

 

 

17


LOGO

 

NOTES FOR CERTAIN INCOME STATEMENT LINE ITEMS - NON-GAAP

(in thousands)

 

(1) Expenses, including legal and consulting fees, incurred in connection with the Company’s acquisitions of Raptor Pharmaceutical Corp. (“Raptor”) , Crealta Holdings LLC (“Crealta”), Hyperion Therapeutics, Inc. (“Hyperion”), Vidara Therapeutics International Public Limited Company (“Vidara”), its agreement to acquire the worldwide rights to interferon gamma-1b and its withdrawn offer to acquire Depomed Inc. have been excluded.
(2) During the three months ended March 31, 2017, the Company recorded a loss on debt extinguishment of $533, which was comprised of the write-off of $388 in debt discount and deferred financing costs, and an early redemption payment of $145.
(3) During the three months ended March 31, 2017, the Company expensed $4,143 of arrangement and other fees relating to the refinancing of its term loans.
(4) Intangible amortization expenses are associated with the Company’s intellectual property rights, developed technology and customer relationships of ACTIMMUNE, BUPHENYL, KRYSTEXXA, LODOTRA, MIGERGOT, PENNSAID 2%, PROCYSBI, RAVICTI, RAYOS and VIMOVO.
(5) Represents amortization of debt discount and deferred financing costs associated with the Company’s debt.
(6) Represents accretion expense associated with the ACTIMMUNE, BUPHENYL, KRYSTEXXA, MIGERGOT, PROCYSBI, RAVICTI and VIMOVO royalties for the three months ended March 31, 2017 and represents accretion expense associated with the ACTIMMUNE, BUPHENYL, KRYSTEXXA, MIGERGOT, RAVICTI and VIMOVO royalties for the three months ended March 31, 2016.
(7) In connection with the Crealta acquisition, the KRYSTEXXA and MIGERGOT inventory was stepped up in value by $144,289 and during the three months ended March 31, 2017, the Company recognized in cost of goods sold, $14,357 for step-up inventory expenses related to KRYSTEXXA and MIGERGOT inventory sold. During the three months ended March 31, 2016, the Company recognized in cost of goods sold, $7,446 for step-up inventory expenses related to KRYSTEXXA and MIGERGOT inventory sold.

In connection with the Raptor acquisition, the PROCYSBI and QUINSAIR inventory was stepped up in value by $66,950 and during the three months ended March 31, 2017, the Company recognized in cost of goods sold $26,238 of step-up inventory expenses related to PROCYSBI and QUINSAIR inventory sold.

 

(8) At the time of the Company’s acquisition of the rights to ACTIMMUNE, BUPHENYL, KRYSTEXXA, MIGERGOT, PROCYSBI, RAVICTI and VIMOVO, the Company estimated the fair value of contingent royalties payable to third parties using an income approach under the discounted cash flow method, which included revenue projections and other assumptions the Company made to determine the fair value. If the Company significantly overperforms or underperforms against its original revenue projections or it becomes necessary to make changes to assumptions as a result of a triggering event, the Company is required to reassess the fair value of the contingent royalties payable. Any subsequent adjustment to fair value is recorded in the period such adjustment is made as either an increase or decrease to royalties payable, with a corresponding increase or decrease in cost of goods sold, in accordance with established accounting policies. During the three months ended March 31, 2017, the Company recorded a net reduction of $2,944, to cost of goods sold to adjust the amount of the contingent royalty liabilities relating to VIMOVO and KRYSTEXXA.
(9) Represents share-based compensation expense associated with the Company’s stock option, restricted stock unit, and performance stock unit grants to its employees and non-employees, its cash-settled long-term incentive program and its employee stock purchase plan.
(10) Represents depreciation expense related to the Company’s property, equipment, software and leasehold improvements.

 

18


LOGO

 

(11) During the year ended December 31, 2016, the Company committed to spend $14,900 related to the harmonization of the manufacturing processes for ACTIMMUNE and IMUKIN drug substance. During the three months ended March 31, 2017, the Company incurred $5,774 of this spend, including costs of $4,299 that qualify for exclusion in the Company’s non-GAAP financial measures under the Company’s non-GAAP cost policy.
(12) Royalties of $11,317 were incurred during the three months ended March 31, 2017, based on the periods’ net sales for ACTIMMUNE, BUPHENYL, KRYSTEXXA, MIGERGOT, PROCYSBI, RAVICTI and VIMOVO. Royalties of $8,500 were incurred during the three months ended March 31, 2016, based on the period’s net sales for ACTIMMUNE, BUPHENYL, KRYSTEXXA, MIGERGOT, RAVICTI and VIMOVO.
(13) Income tax adjustments on pre-tax non-GAAP adjustments represent the estimated income tax impact of each pre-tax non-GAAP adjustment based on the statutory income tax rate of the applicable jurisdictions for each non-GAAP adjustment.
(14) Represents an upfront fee paid for a license of a global patent.

 

19